Is Stem Cell Therapy the Future of Orthopedics?

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Is Stem Cell Therapy the Future of Orthopedics?

A significant increase in number of articles on the treatment effect of stem cell therapy have been published in recent years. While the techniques in orthopedic surgery such as knee arthroplasty (TKA) and anterior cruciate ligament (ACL) reconstruction have demonstrated considerable advancement, the restoration of normal biomechanics and proprioception still remain the fundamental challenge. Therefore the budding interest of researchers in regenerative medicine.

Amidst the various methods that have used for improving healing and regeneration, mesenchymal stem cell (MSC) therapy is one of the conventionally used approaches. MSCs have high proliferative potential and the capacity to divide into chondrocytes, osteoblasts and adipocytes. Further to their multilineage potential, MSCs have enhanced therapeutic functions in response to injury, including immune modulation and trophic activities. The theme of the present challenge of Knee Surgery & Related Research is stem cells. The existing issue consists of three articles on this theme including literature review, meta-analysis and original article.

The literature review by Huri et al., portrayed the latest advances and potential trends in using infrapatellar fat pad-derived stem cells (IPFP-ASCs) and their preclinical and clinical implications. The meta-analysis by Shin et al. synthesized 8 articles to determine clinical and magnetic resonance imaging (MRI) outcomes after surgery in patients with knee osteoarthritis (OA) treated with bone marrow-derived MSCs (BM-MSCs). The other article analysed the regenerative potential of ACL-derived MSCs (ACL-MSCs) from old donors with ACL-MSCs from young donors.

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